Poster 260: Influence of Donor Demographics on Graft Survival following Knee Osteochondral Allograft Transplantation

Objectives: To evaluate whether donor and recipient factors such as age, sex mismatch, time from death to graft implantation affect survival following knee osteochondral allograft (OCA) transplantation. Methods: Patients undergoing OCA transplantation in the 2003-2016 were prospectively followed. Inclusion criteria consisted of primary minimum 2-year follow-up. Patient demographic data collected. evaluated for failure, defined (1) subchondral collapse confirmed on postoperative MRI scans, or via second-look arthroscopy setting persistent symptoms, (2) removal revision OCA, (3) conversion arthroplasty. Multivariate cox proportional hazards modelling was utilized associations between variables failure. Results: A total 220 patients met inclusion followed a mean 5.9 ± 2.8 years (range: 2.0 – 16.3, Table 1). The most common concomitant procedure meniscal (Table 2). mismatch present significantly more female (65%) than male (10%, p < 0.001). days until 24.1 15 28). Thirty-nine (18%) failure at 4.3 3.2 3). Log-rank testing did not determine difference survivability those with donor-recipient (P = .130 .831, respectively). Upon multivariate regression, no association existed survival. Of note, increased age associated .020) trended towards significance males .166). Conclusions: appears be strongly influenced by age. In contrast previous historic data, substantial noted mismatched donors recipients. These can help inform selection outcome optimization OCA. [Table: see text][Table: text]